Beilstein J. Nanotechnol.2016,7, 1871–1877, doi:10.3762/bjnano.7.179
effects on cells caused by nanomaterials, preferably by label-free, noninvasive, fast, and cost effective methods. These requirements can be met by monitoring cell viability with a capacitance-sensing integrated circuit (IC) microchip. The capacitance provides a measurement of the surface attachment of
medium above the capacitors. Moreover, the manufacturing of microfluidic channels in the LTCC package was demonstrated.
Keywords: capacitancesensing; cell viability; lab-on-a-chip; low temperature co-fired ceramic (LTCC); Introduction
Biosafety regulations require ethical, simple, rapid, and cost
capacitancesensing and the intention is to develop a method for nanoparticle exposure of cells to establish cytotoxicity assessment of nanomaterials.
Capacitance measurements reflect the surface attachment of adherent cells. While healthy cells attach to the cultivation surface and spread out, dying cells
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Figure 1:
(a) Layout of the dummy chip mimicking the size of the sensor chip and the contact pad positions an...